There are certainly steps that you can take to help reduce the chances.
1. Make sure that you don't leave your baby in a wet or dirty diaper for a prolonged period
2. Keep your eyes on areas where the diaper maybe rubbing.
3. Some brands of diapers have potential for more irritants.
4. Take preventative steps, like applying diaper rash.

From being the first company to produce a 100% BPA free baby bottle to their award-winning sun care line, Thinkbaby has a long history of building safe, non-toxic products for babies to athletes (Thinksport). Their mineral based diaper rash furthers their movement into baby body care with an ingredient list made up of  natural and organic ingredients.